Best Brain Fitness Supplements for 2021

Brain Fitness Supplements Overview

Nootropics are meant to boost cognitive function, increasing memory, creativity, and decision-making, and they’re a growing market in recent years. Nootropics work by giving you more access to certain brain chemicals, called neurotransmitters, that can enhance brain function.

But with so many brain fitness supplements out there, it can feel next to impossible to figure out which ones are legit.

What to Look for in a Brain Supplement

We’ve broken down the most important things to consider when choosing a brain supplement below. We use these criteria when deciding which supplements to recommend, and you might want to consider the following when you’re doing your own research on new supplements to try, whether you choose one from this list or not.

Reputable Company

The first thing to look for when looking at a new supplement is the company that makes it.

Because dietary supplements are classified as food rather than drugs, they’re not regulated very well. That means you’re relying on the manufacturer to make a safe, high-quality product with little or no oversight.

Brain fitness supplements can range from potent products to low-quality pills with lots of filler – you just never know. That’s why it’s so crucial to research the company you’re buying from and get an idea of how long they’ve been in business and their overall reputation.

Proven Ingredients

The next thing to take into account is the ingredients used in a supplement. Every few years, there’s a new superfood or wonder herb that’s supposed to cure everything. But if you want to get the most out of your money, stick with ingredients that have been clinically tested and stand the test of time.

It never hurts to research each ingredient separately, so you can get a clear, unbiased picture of its benefits and potential side effects.

Plus, it’s always a good idea to talk with your doctor before trying a new supplement to avoid any potential allergic reactions or unforeseen side effects.

Customer Satisfaction

Lastly, you should look at is good old fashioned customer reviews.

Thanks to the internet, it’s easier than ever to get a feel for how real customers feel about a product, and they don’t hold back. Be sure to read several reviews before making a decision, so you can benefit from others’ experiences when making your decision.

Best Brain Fitness Supplements

Although all brain fitness supplements are designed to improve mental functioning, not all are created equal. We’ve found the best ones around and broken down the highlights of each one to give you a better idea of which one will work for you.

We evaluated based on:

  • Use of time-tested ingredients
  • Overall benefits provided by the supplement
  • Customer satisfaction
  • Company reputation

These descriptions will give you an idea of what the supplement promises, how it delivers the promised benefits, and what actual customers think about the products.

1 Body Brain Support

Brain Support Focus Supplement Pills - Support Healthy Brain Function with Nootropics, Improve Memory and Boost Focus - Alpha GPC, Lions Mane Extract, Bacopa Monnieri
  • Improve Memory & Learning - Nourish your mind with brain supplements that promote better recall & memory retention to improve your communication skills, enhance learning & access to memories
  • Enjoy Greater Focus & Clarity - Nothing turns you into a pro faster than having better focus concentration and mental clarity to attack your work and studies now without feeling the constant pressure to get distracted
  • Clinically Proven Nootropic Ingredients - Support healthy brain function and peak mental performance. Our formula contains Alpha GPC Bacopa Monnieri Ginkgo Biloba Rhodiola Rosea Huperzine A & more
  • Clean Energy & Mood Booster - Our formula provides clean calm energy with no caffeine or harsh stimulants. Plus it includes nutrition to elevate mood & reduce stress
  • Non-GMO & Vegetarian - Our smart brain supplement contains 30 servings of 3 easy-to-swallow pills. Manufactured in the USA at a cGMP facility with NO dairy, gluten, soy, egg, fish, tree nuts, & no artificial colors or flavors


Vegetarians can have trouble finding appropriate nootropics since many contain fish oil and other animal products. But 1 Body Brain Support is made of 100% vegetarian ingredients, using such herbs and extracts as:

  • Ginkgo biloba
  • Lion’s mane
  • Alpha GPC
  • Taurine
  • Bacopa


  • Vegetarian ingredients
  • Greater focus and improved memory
  • Faster word recall during conversation
  • More energy overall
  • Clearer mind, less brain fog


  • No additional vitamins

Unlike some others on this list, the ingredients in this supplement focus almost exclusively on brain health – the only additional vitamins included are B12 and B6. That makes it ideal for those who like to take products only as needed, rather than popping a dozen extra vitamins with their nootropics unnecessarily.

Vital Vitamins Brain Booster

VITAL VITAMINS Brain Supplement Nootropics Booster - Enhance Focus & Mind, Boost Concentration, Improve Memory & Clarity for Men Women, Ginkgo Biloba,Dmae,Iq Neuro Energy, Vitamin B12 Bacopa Monnieri
  • Memory, Focus & Clarity - Our Brain Booster is a brain support supplement for both men and women, formulated with nootropic ingredients. Whether you're a college student, a workaholic, an athlete, or a busy parent, our supplements can help get you through any challenge life throws at you!
  • Energize Yourself - Brain Booster delivers nootropics which can help reduce fatigue. Developed as a focus supplement, our booster includes key ingredients like Dmae, which may help produce feelings of mental clarity, cognitive ability, memory and physical energy without the crash.
  • Stay Focused – Say goodbye to brain fog and be done with distractions. Each brain health supplement capsule delivers ingredients designed to support alertness for your everyday life. When the mind is active and in the right state, logical reasoning and creativeness are enhanced.
  • Premium Ingredients - Our Brain Booster supplement is made with vitamins and minerals, as well as with herbal extracts. It's non-GMO and free of hormones and gluten.
  • A Brand You Can Trust - This advanced memory supplement for the brain is professionally formulated in the USA in a GMP certified facility to ensure high quality production. Get your Brain Booster memory pills today!


Made right here in the USA, Vital Vitamins Brain Booster provides users with a potent, high-quality nootropic meant to improve memory, focus, and clarity.


  • Clear-headed feeling
  • Improved memory
  • Better mood


  • No extra vitamins

The herbal extracts used, such as ginkgo biloba, phosphatidylserine, and Rhodiola Rosea Extract, are tried-and-true herbal supplements for brain fitness.

Ancestral Supplements Grass Fed Brain

Ancestral Supplements Grass Fed Beef Brain Supplement with Beef Liver, Whole Food Brain Support Promotes Brain, Mood, and Memory Health, Brain and Liver Health Formula Capsules, Non-GMO, 180 Capsules
  • Time-Honored Brain Supplements: Grounded in the wisdom of ancient practices, our brain organ meat supplements are rich in glandulars specific to the brain, including pituitary, hypothalamus and pineal glands, and support overall brain health*
  • Neuron Support: Included in this whole-brain-extract memory and mood support supplement are neurotrophic factors, such as nerve-growth factor (BDNF), that support the survival of existing neurons and encourage the growth of new neurons*
  • Added Support from Liver: Our brain health formula includes beef liver, a nourishing nutritional powerhouse that not only supports brain function, memory, and mood, but also supports skin, hair, connective tissue, immune function, and heart health
  • New Zealand and Australian Grass-Fed Beef: Made in small batches in the USA without GMOs, fillers, or flow agents and third party tested for purity, our supplements are sourced from 100% grass fed cows, pasture-raised without hormones in green fields
  • Dense Nutrition for Mood and Memory: As the founders of the Beef Organ Movement, our mission is to make vital nutrition through the highest possible quality organ consumption accessible for all, putting back in what the modern world has left out


Ancestral Supplements Grass Fed Brain is quite a bit different than the other supplements on this list since it doesn’t use herbs to boost brain function. If the name didn’t give it away, this supplement contains the brains (and livers) of grass-fed cattle. The company works on the theory that “like supports like,” so if you want to improve your brain health, you should eat the brain of a healthy animal.


  • 100% grass-fed bovine
  • Less brain fog
  • Better mood
  • Improved sleep
  • More motivation
  • Quicker brain function


  • Not vegetarian friendly

In addition to the theory that eating a healthy brain will make your function better, these capsules provide your body with a hefty dose of omega 3 fats, peptides, and neurotrophic proteins. The animals harvested for all Ancestral supplements are raised in the green pastures of New Zealand and are free of hormones and GMOs.

Focus Factor Extra Strength

Focus Factor Extra Strength, 120 Count - Brain Supplement for Memory, Concentration and Focus - Complete Multivitamin with DMAE, Vitamin D, DHA - Trusted Brain Health Supplement - Brain Vitamins
  • COMPLETE MULTIVITAMIN IMPROVES FOCUS: Focus Factor Extra Strength brain supplements contain a powerful combination of vitamins, minerals, and neuro-nutrients, that not only power your brain but can also replace your daily multivitamin
  • PROMOTES CONCENTRATION and MEMORY: Like other parts of your body, your brain needs proper nutrition to perform its best. This advanced formula improves and enhances memory, concentration, and your ability to focus
  • PREMIUM INGREDIENTS: Focus Factor brain support supplements are enriched with a powerful combination of premium ingredients like bacopa, ginkgo biloba, phosphatidylserine, DMAE, and a comprehensive blend of vitamins and minerals
  • QUALITY FORMULA: Focus Factor Extra Strength takes the original Focus Factor formula and increases the levels of key selected neuro-nutrients. Our brain focus formula contains no artificial colorings or sweeteners
  • FOCUS FACTOR: We offer a range of products designed to help you find your focus. Focus Factor has been America’s brain health supplement brand for nearly 20 years, with formulas for the whole family


If you’re the type of person who doesn’t like taking a handful of different pills every day, you might want to consider Focus Factor Extra Strength. This supplement provides you with 24 vital vitamins and minerals in addition to a brain-focused herbal blend, so you can replace your regular daily vitamins with it.


  • Can replace daily multivitamin
  • Feeling more youthful (in body and mind)
  • Feeling more energized
  • A noticeable difference if they forget to take it or switch to something else
  • Results within days


  • Large pill size

The main problem with Focus Factor is the pill size, which is relatively large. If you have trouble swallowing large pills, you might want to add a pill cutter to your cart when you place your order.

This clinically tested formula aims to improve neuro and overall health, and their studies show a clear improvement in memory, focus, and concentration after six weeks of use.


Prevagen Improves Memory - Extra Strength 20mg, 30 Capsules, with Apoaequorin & Vitamin D & Prevagen 7-Day Pill Minder | Brain Supplement for Better Brain Health, Supports Healthy Brain Function
  • In a double-blinded, placebo-controlled trial, Prevagen demonstrated the ability to improve aspects of cognitive function in subgroups of participants who were cognitively normal or mildly impaired.* The group of participants taking Prevagen improved according to computer-based testing.* The adults were over 40 years old and took one capsule daily for 90 days
  • Apoaequorin, the unique ingredient in Prevagen, has undergone extensive SAFETY TESTING. Tests for allergenicity and toxicity have been conducted. Third party experts agree that PREVAGEN IS SAFE
  • Prevagen Extra Strength comes in an EASY TO SWALLOW capsule. For best results, just take ONE A DAY, in the morning, with or without food
  • According to a 2021-2022 survey conducted by Pharmacy Times of pharmacists who recommend memory support products, Prevagen was the #1 recommended Memory Support brand
  • Includes a Prevagen 7-day Pill Minder to help you stay organized. Made in the USA, BPA free, letters & braille for days of the week


Prevagen backs up their claims to improve mental functioning with double-blind placebo studies, adding a level of credibility to their product. Rather than claiming to be an end-all-be-all product, Prevagen focuses on reversing age-related memory loss.


  • Improved memory with regular use
  • Better word recall while speaking


  • Only focuses on specific issues, rather than overall brain fitness

If you’re looking for a brain fitness supplement that will boost a specific area of brain function without a lot of extras, this one’s worth a look.

The Genius Brand Genius Mushrooms

Genius Mushroom – Lions Mane, Cordyceps and Reishi – Immune System Booster & Nootropic Brain Supplement – Wellness Formula for Natural Energy, Memory & Liver Support, 90 Veggie Pills
  • NURTURE YOUR MIND, BODY & SPIRIT – By combining 3 of the most researched mycological species on the planet, Genius Mushrooms deliver an organic wellness formula unlike any other: Enhance mental clarity, immune function, natural energy and more
  • IMMUNE SYSTEM BOOSTER – Elevate immune support to another level with reishi mushroom extract: Having been used for centuries, this immune booster is what you need daily to stay healthy and avoid the common cold
  • MEMORY, FOCUS & COGNITIVE PERFORMANCE – Lions Mane provides a safe alternative to highly questionable nootropics and smart drug hitting the market nowadays: This species is a proven brain booster, great for work & studying
  • CAFFEINE FREE ENERGY SUPPLEMENT – Elevate your energy levels naturally via ATP production with Cordyceps Sinensis: Increase oxygen utilization, aerobic capacity and athletic endurance without stimulants
  • LIVER SUPPORT & DETOX – Reishi has also been shown to improve mood and to potentially act as a detoxifying liver cleanse: There isn’t another wellness formula on the market that delivers like this (Packaging may slightly vary).


The Genius Brand Genius Mushrooms are perfect for people who like to keep their supplements simple. These veggie capsules don’t list dozens of unpronounceable ingredients that you’ve never heard of. They simply harvest the benefits of three powerful mushrooms:

  • Reishi: detoxifies and improves mood
  • Lion’s Mane: improves cognitive and immune system function
  • Cordyceps: increases energy and endurance

Genius Mushrooms are another nootropic that aims to improve neuro functioning while supporting the body as a whole.


  • Alert, yet calm, mind state
  • Lowered levels of stress and anxiety
  • More physical energy
  • Greater ability to concentrate and retain information


  • None

The mushrooms used by The Genius Brand are organic and go through rigorous purity testing for the safest, most natural way to boost your brain fitness.

Nature’s Bounty Ginkgo Biloba

Nature’s Bounty Ginkgo Biloba Capsules 120mg, Memory Support Supplement, Supports Brain Function and Mental Alertness, 100 Capsules
  • GINKGO BILOBA SUPPLEMENT: Nature's Bounty's Ginkgo Biloba 120 mg standardized extract may help maintain healthy circulation & may help support mental alertness & healthy brain function, perfect for occasional mild memory problems associated with aging
  • MENTAL ALERTNESS & MEMORY: Used in China in the 15th century for its healthy properties, Ginkgo Biloba may help support healthy brain function, mental alertness and support memory, especially occasional mild memory problems associated with aging.Sodium free
  • MINERALS FOR MOOD: Nature’s Bounty Calcium-Magnesium and can support a calm, relaxed mood
  • NATURE'S BOUNTY FOR A HEALTHY LIFE: At Nature's Bounty, we want to help you maintain wellness at every stage of life & carry a range of vitamins & supplements including prenatal vitamins, mood support, joint support & supplements for healthy aging
  • GUARANTEED QUALITY: Nature's Bounty nutritional supplements meet high quality standards Try them if you've enjoyed supplements from Garden of Life, Vitafusion, Rainbow Light, Centrum, Alive, Solgar, Nordic Naturals, or Nature Made


It doesn’t get more straightforward than Nature’s Bounty Ginkgo Biloba, which relies on one powerful herb to restore and enhance brain function. Ginkgo Biloba has been used for centuries to:

  • Enhance mental alertness
  • Improve memory
  • Increase circulation
  • Support healthy brain function


  • Simple, natural formula
  • Improved short term memory
  • Improved mood
  • More pronounced benefits over time


  • No vitamins or minerals

Nature’s Bounty is so confident that ginkgo biloba will boost your brain fitness that they don’t feel the need to add anything else – just the pure herb enclosed in a gelatin capsule. The company uses lab-tested herbs to ensure high-quality products.

Nature’s Nutrition Brain Support Supplement


Nature’s Nutrition Brain Support Supplement contains 40 brain-boosting ingredients that work in synergy to improve your brain fitness. The natural ingredients are combined using strict guidelines with frequent outside checks to ensure safety, purity, and potency.

The proprietary blend includes:

  • Bacopa monnieri
  • DMAE bitartrate
  • L-glutamine
  • Green tea extract

But it also contains a host of vitamins and minerals, providing your body with the energy to support brain fitness.


  • The low price
  • The increased mental clarity
  • The ability to focus and recall information


  • Not ideal for those seeking a simple ingredient list

If you suffer from distractibility or lack of focus, Nature’s Nutrition Brain Support Supplement is one to try.

Natures Craft Neuro Health

Nootropics Brain Supplement Support - Memory Booster for Mind Focus - DMAE Pills for Concentration Improve Brain Function Neuro & IQ with Bacopa Monnieri and L-Glutamine for Men and Women
  • More Brain Power- natural extract of Green Tea and brain nutrients increases energy in our best selling herbal supplement for memory and cognition, add to teas, energy drinks and more
  • Improve memory - games, books, techniques take time. Natures Craft mind enhancement supplement is fast way to enhance performance using nootropic brain boosting stack of natural extracts
  • Better Focus & Concentration- the organic way to focus and get work done- Bacopa Monniera is well known, trusted supplement for attention- capsules contain 20 mg of Bacosides chemical compounds
  • Enhance Mental Crality- also called smart pills, neuroprotective capsules contain potent ingredients like Gaba- may improve brain focus thanks to an array of brain vitamins to clear away brain fog
  • Lift your Mood- Green Tea Extract is traditional mood and attitude helper- we also increase nootropic stacking combination with Bilberry Fruit Extract, L Glutamine, Phosphatidylserine and Huperzine A


Natures Craft Neuro Health is another example of a brain fitness supplement that you could easily use to replace your multivitamin. With 22 vitamins and minerals in addition to a proprietary brain blend, this supplement packs a punch.


  • Extra vitamins and minerals
  • Boosts mental clarity and focus
  • Gives a feeling of non-jittery alertness
  • Improves memory and recall


  • Not ideal for as-needed use

As with many herbal supplements, this product tends to work best over time, rather than an as-you-need-it approach.

Neuriva Brain Performance

NEURIVA Plus Brain Supplement For Memory, Focus & Concentration + Cognative Function with Vitamins B6 & B12 and Clinically Tested Nootropics Phosphatidylserine and Neurofactor, 30ct Capsules
  • NOOTROPIC BRAIN SUPPORT CAPSULES: Clinical studies have shown that coffee cherry Neurofactor and plant-sourced PS phosphatidylserine have a positive effect on brain health.
  • MENTAL PERFORMANCE: Clinically tested Neurofactor helps support focus, concentration & accuracy, while Clinically tested Plant-Sourced phosphatidylserine helps fuel memory & learning. With B Vitamins to help support cognitive function.
  • CLINICALLY TESTED NEUROFACTOR: This whole fruit extract has been Clinically tested & shown to increase levels of the vital neuroprotein BDNF brain-derived neurotrophic factor. BDNF is known to support connections between brain cells.
  • HOW TO USE: Adults 18 years and older take one capsule daily at bedtime for better results.
  • TRUSTWORTHY INGREDIENTS: These brain health capsules were formulated with you in mind, so they are Vegetarian, Gluten-Free, GMO-Free and Decaffeinated.


Neuriva Brain Performance is a basic vegetarian nootropic that promises improved:

  • Learning
  • Focus
  • Memory
  • Reasoning
  • Accuracy
  • Concentration

This supplement includes a couple of B vitamins as well as folate, but the main ingredients are:

  • Coffee cherry: strengthens the connection between brain cells
  • Phosphatidylserine: improves brain performance


  • Simple, natural ingredient list
  • Increases alertness
  • Provides a greater sense of wellbeing


  • None

Neuriva Brain Performance is so keen to improve your brain fitness that it comes with a brain-boosting app, too.

Nordic Naturals Ultimate Omega

Nordic Naturals Ultimate Omega, Lemon Flavor - 90 Soft Gels - 1280 mg Omega-3 - High-Potency Omega-3 Fish Oil Supplement with EPA & DHA - Promotes Brain & Heart Health - Non-GMO - 45 Servings
  • WHY OMEGA-3S - Research shows that the essential fatty acids EPA & DHA in fish oil support heart, brain, eye & immune health. Omega-3s may also help support a healthy mood.
  • #1 FISH OIL BRAND IN THE U.S.** - Nordic Naturals Ultimate Omega features high concentration omega-3 fish oil in soft gels. This formula meets the daily recommended dose suggested by the American Heart Association to support a healthy heart. **Source: ClearCut Analytics Amazon Segment Sales last 12 months ending Feb 28, 2021.
  • BETTER ABSORPTION, BETTER TASTE, NO FISHY BURPS - All of our omega-3 fish oil concentrates are in the triglyceride molecular form (the form naturally found in fish) for optimal absorption. Ultimate Omega has a great lemon taste.
  • PURITY GUARANTEED - Every batch of Nordic Naturals fish oil is crafted from fresh, wild-caught, omega-rich fish. We are committed to using only non-GMO, gluten- & dairy-free ingredients with no artificial colors, flavors, or preservatives.
  • ETHICAL INNOVATION - Nordic Naturals has always been at the forefront of sustainable & ethical practices in the natural products industry. Through science & innovation, we are committed to delivering safe, effective nutrients for optimal wellness.


Nordic Naturals Ultimate Omega isn’t marketed as a brain fitness supplement, but it provides you with a hearty dose of high potency omega 3 oils from anchovies and sardines.

Omega 3s are said to improve:

  • Cognitive function
  • Heart health
  • Eyesight
  • Immune system

If you’re looking for a basic all-in-one supplement that will improve your overall health in addition to brain fitness, you might want to check this one out.


  • Potent Onega 3 oils
  • Easier time concentrating
  • Less joint pain and inflammation
  • More energy


  • Reliant on one main ingredient

Nordic Naturals uses only wild-caught fish in their products, using ethical and sustainable practices.

ONNIT Alpha Brain

Onnit Alpha Brain Premium Nootropic Brain Supplement, 90 Count, for Men & Women - Caffeine-Free Focus Capsules for Concentration, Brain & Memory Support - Brain Booster Cat's Claw, Bacopa, Oat Straw
  • Alpha Brain Daily Cognitive Support: Combat occasional brain fog and boost focus with the Onnit Alpha Brain Booster Supplement! These brain supplements for memory and focus are the ideal way for men and women to enhance their focus and cognitive speed.
  • Enhance Your Focus: Whether you’re focusing on your career, academics, social life, or athletics, this memory supplement for the brain is a nootropic supplement that helps support memory, mental speed and focus to promote lasting mental clarity.
  • Carefully Selected Ingredients: These brain vitamins are formulated with high-quality nutrients to help support focus. They include Cat’s Claw Extract, Bacopa, Oat Straw, Huperzia Serrata, and our Focus and Flow Blends to help you realize limitless potential.
  • Quality Formulas: Designed to help reduce memory fog, these brain supplements are stimulant-free, so you don’t have to worry about afternoon crashes. Our memory capsules contain no caffeine, dairy, nuts, or gluten, and they are paleo and keto-friendly.
  • Leading Nootropics Since 2011: The ultimate way to support memory, brain focus, and cognitive processing speed, Alpha Brain memory supplements have been a market leader in nootropic brain boost since 2011 with over 1 million bottles sold.


If there’s one nootropic that just about everyone has heard about, it’s got to be ONNIT Alpha Brain, which is leading the charge in brain fitness supplements. With over a million bottles sold, Alpha Brain is one of the most popular nootropics around, promising improvements in all areas of life:

  • Work and academics
  • Sports
  • Social Situations

Die-hard fans of this product include Joe Rogan and comedian Pete Holmes.


  • Feeling of being “in the zone”
  • Easier conversations
  • Alert yet calm
  • Greater mental focus


  • Can cause stomach upset

Alpha Brain aims to boost mental and physical performance, so you can reach your potential in every aspect of your life.

Wrap Up

Now that you know a little more about each of the top brain fitness supplements, you can make an informed decision when choosing the best nootropic for you.

Our personal favorite is the Focus Factor Extra Strength, thanks to the two dozen vitamins that it provides in addition to the brain supplement.

But don’t take our word for it – always be sure to do your research and read customer reviews before choosing a health supplement of any kind. Remember, for supplements to be as effective as possible, you should pair them with an overall healthy lifestyle.

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